Hertz B, Dilling D, Garrity E.
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease, in which abnormal amounts of surfactant-rich material accumulate in the alveoli and interfere with gas exchange. Clinically, PAP is characterized by the insidious onset of exertional dyspnea and cough.(1) Less common symptoms include fatigue, weight loss, and fever, which typically occur if secondary infection is present.(1)